Phylogenetic Quantification of Intra-tumour Heterogeneity

Intra-tumour genetic heterogeneity is the result of ongoing evolutionary change within each cancer. The expansion of genetically distinct sub-clonal populations may explain the emergence of drug resistance, and if so, would have prognostic and predictive utility. However, methods for objectively qua...

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Main Authors: Schwarz, Roland F., Trinh, Anne, Sipos, Botond, Brenton, James D., Goldman, Nick, Markowetz, Florian
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990475/
https://ncbi.nlm.nih.gov/pubmed/24743184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003535
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