Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells

Natural and synthetic triterpenoids have been shown to kill cancer cells via multiple mechanisms. The therapeutic effect and underlying mechanism of the synthetic triterpenoid bardoxolone methyl (C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; CDDO-Me) on esophageal cancer are unc...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Wang, Yan-Yang, Yang, Yin-Xue, Zhao, Ren, Pan, Shu-Ting, Zhe, Hong, He, Zhi-Xu, Duan, Wei, Zhang, Xueji, Yang, Tianxin, Qiu, Jia-Xuan, Zhou, Shu-Feng
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2015
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338783/
https://ncbi.nlm.nih.gov/pubmed/25733817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S73493
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