Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells

Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of advanced solid tumor and hematologic malign...

Full description

Saved in:
Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Ding, Yong-Hui, Zhou, Zhi-Wei, Ha, Chun-Fang, Zhang, Xue-Yu, Pan, Shu-Ting, He, Zhi-Xu, Edelman, Jeffrey L, Wang, Dong, Yang, Yin-Xue, Zhang, Xueji, Duan, Wei, Yang, Tianxin, Qiu, Jia-Xuan, Zhou, Shu-Feng
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2015
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296919/
https://ncbi.nlm.nih.gov/pubmed/25624750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S74062
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items