Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells

Natural and synthetic triterpenoids have been shown to kill cancer cells via multiple mechanisms. The therapeutic effect and underlying mechanism of the synthetic triterpenoid bardoxolone methyl (C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; CDDO-Me) on esophageal cancer are unc...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Wang, Yan-Yang, Yang, Yin-Xue, Zhao, Ren, Pan, Shu-Ting, Zhe, Hong, He, Zhi-Xu, Duan, Wei, Zhang, Xueji, Yang, Tianxin, Qiu, Jia-Xuan, Zhou, Shu-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338783/
https://ncbi.nlm.nih.gov/pubmed/25733817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S73493
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