Hyperhomocysteinemia and Hyperglycemia Induce and Potentiate Endothelial Dysfunction via μ-Calpain Activation

Plasma homocysteine (Hcy) levels are positively correlated with cardiovascular mortality in diabetes. However, the joint effect of hyperhomocysteinemia (HHcy) and hyperglycemia (HG) on endothelial dysfunction (ED) and the underlying mechanisms have not been studied. Mild (22 µmol/L) and moderate (88...

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Dades bibliogràfiques
Publicat a:Diabetes
Autors principals: Cheng, Zhongjian, Jiang, Xiaohua, Pansuria, Meghana, Fang, Pu, Mai, Jietang, Mallilankaraman, Karthik, Gandhirajan, Rajesh Kumar, Eguchi, Satoru, Scalia, Rosario, Madesh, Muniswamy, Yang, Xiaofeng, Wang, Hong
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2015
Matèries:
Pathophysiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338586/
https://ncbi.nlm.nih.gov/pubmed/25352635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0784
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