Hyperhomocysteinemia and Hyperglycemia Induce and Potentiate Endothelial Dysfunction via μ-Calpain Activation

Plasma homocysteine (Hcy) levels are positively correlated with cardiovascular mortality in diabetes. However, the joint effect of hyperhomocysteinemia (HHcy) and hyperglycemia (HG) on endothelial dysfunction (ED) and the underlying mechanisms have not been studied. Mild (22 µmol/L) and moderate (88...

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Vydáno v:Diabetes
Hlavní autoři: Cheng, Zhongjian, Jiang, Xiaohua, Pansuria, Meghana, Fang, Pu, Mai, Jietang, Mallilankaraman, Karthik, Gandhirajan, Rajesh Kumar, Eguchi, Satoru, Scalia, Rosario, Madesh, Muniswamy, Yang, Xiaofeng, Wang, Hong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2015
Témata:
Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338586/
https://ncbi.nlm.nih.gov/pubmed/25352635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0784
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