Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor–mediated vasorelaxation in transgenic cystathionine beta synthase–deficient mice

Hyperhomocysteinemia (HHcy) is associated with endothelial dysfunction (ED), but the mechanism is largely unknown. In this study, we investigated the role and mechanism of HHcy-induced ED in microvasculature in our newly established mouse model of severe HHcy (plasma total homocysteine, 169.5μM). We...

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Detalhes bibliográficos
Main Authors: Cheng, Zhongjian, Jiang, Xiaohua, Kruger, Warren D., Praticò, Domenico, Gupta, Sapna, Mallilankaraman, Karthik, Madesh, Muniswamy, Schafer, Andrew I., Durante, William, Yang, Xiaofeng, Wang, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158725/
https://ncbi.nlm.nih.gov/pubmed/21653942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-333310
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