Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor–mediated vasorelaxation in transgenic cystathionine beta synthase–deficient mice

Hyperhomocysteinemia (HHcy) is associated with endothelial dysfunction (ED), but the mechanism is largely unknown. In this study, we investigated the role and mechanism of HHcy-induced ED in microvasculature in our newly established mouse model of severe HHcy (plasma total homocysteine, 169.5μM). We...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Cheng, Zhongjian, Jiang, Xiaohua, Kruger, Warren D., Praticò, Domenico, Gupta, Sapna, Mallilankaraman, Karthik, Madesh, Muniswamy, Schafer, Andrew I., Durante, William, Yang, Xiaofeng, Wang, Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Vascular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158725/
https://ncbi.nlm.nih.gov/pubmed/21653942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-333310
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge