Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor–mediated vasorelaxation in transgenic cystathionine beta synthase–deficient mice

Hyperhomocysteinemia (HHcy) is associated with endothelial dysfunction (ED), but the mechanism is largely unknown. In this study, we investigated the role and mechanism of HHcy-induced ED in microvasculature in our newly established mouse model of severe HHcy (plasma total homocysteine, 169.5μM). We...

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Detaylı Bibliyografya
Asıl Yazarlar: Cheng, Zhongjian, Jiang, Xiaohua, Kruger, Warren D., Praticò, Domenico, Gupta, Sapna, Mallilankaraman, Karthik, Madesh, Muniswamy, Schafer, Andrew I., Durante, William, Yang, Xiaofeng, Wang, Hong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2011
Konular:
Vascular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158725/
https://ncbi.nlm.nih.gov/pubmed/21653942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-333310
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