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Hyperhomocysteinemia and Hyperglycemia Induce and Potentiate Endothelial Dysfunction via μ-Calpain Activation

Plasma homocysteine (Hcy) levels are positively correlated with cardiovascular mortality in diabetes. However, the joint effect of hyperhomocysteinemia (HHcy) and hyperglycemia (HG) on endothelial dysfunction (ED) and the underlying mechanisms have not been studied. Mild (22 µmol/L) and moderate (88...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Cheng, Zhongjian, Jiang, Xiaohua, Pansuria, Meghana, Fang, Pu, Mai, Jietang, Mallilankaraman, Karthik, Gandhirajan, Rajesh Kumar, Eguchi, Satoru, Scalia, Rosario, Madesh, Muniswamy, Yang, Xiaofeng, Wang, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338586/
https://ncbi.nlm.nih.gov/pubmed/25352635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0784
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