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PKC Upregulates ICAM-1 And Leukocyte-Endothelium Interactions in Hyperglycemia Via Activation of Endothelial Expressed Calpain
OBJECTIVE: We tested the hypothesis of a role for the calcium-dependent protease calpain in the endothelial dysfunction induced by hyperglycemic activation of protein kinase C (PKC). METHODS AND RESULTS: Chronic hyperglycemia with insulin deficiency (Type-1 diabetes) was induced in rats by streptozo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086836/ https://ncbi.nlm.nih.gov/pubmed/21071702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.217901 |
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