PKC Upregulates ICAM-1 And Leukocyte-Endothelium Interactions in Hyperglycemia Via Activation of Endothelial Expressed Calpain

OBJECTIVE: We tested the hypothesis of a role for the calcium-dependent protease calpain in the endothelial dysfunction induced by hyperglycemic activation of protein kinase C (PKC). METHODS AND RESULTS: Chronic hyperglycemia with insulin deficiency (Type-1 diabetes) was induced in rats by streptozo...

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Hauptverfasser: Smolock, Amanda R., Mishra, Gourav, Eguchi, Kunie, Eguchi, Satoru, Scalia, Rosario
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086836/
https://ncbi.nlm.nih.gov/pubmed/21071702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.217901
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