Hyperhomocysteinemia and Hyperglycemia Induce and Potentiate Endothelial Dysfunction via μ-Calpain Activation

Plasma homocysteine (Hcy) levels are positively correlated with cardiovascular mortality in diabetes. However, the joint effect of hyperhomocysteinemia (HHcy) and hyperglycemia (HG) on endothelial dysfunction (ED) and the underlying mechanisms have not been studied. Mild (22 µmol/L) and moderate (88...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Cheng, Zhongjian, Jiang, Xiaohua, Pansuria, Meghana, Fang, Pu, Mai, Jietang, Mallilankaraman, Karthik, Gandhirajan, Rajesh Kumar, Eguchi, Satoru, Scalia, Rosario, Madesh, Muniswamy, Yang, Xiaofeng, Wang, Hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2015
Soggetti:
Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338586/
https://ncbi.nlm.nih.gov/pubmed/25352635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0784
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