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Mouse models of cystathionine β-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia
Untreated cystathionine β-synthase (CBS) deficiency in humans is characterized by extremely elevated plasma total homocysteine (tHcy>200 μM), with thrombosis as the major cause of morbidity. Treatment with vitamins and diet leads to a dramatic reduction in thrombotic events, even though patients...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Federation of American Societies for Experimental Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2653989/ https://ncbi.nlm.nih.gov/pubmed/18987302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-120584 |
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