Mouse models of cystathionine β-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia

Untreated cystathionine β-synthase (CBS) deficiency in humans is characterized by extremely elevated plasma total homocysteine (tHcy>200 μM), with thrombosis as the major cause of morbidity. Treatment with vitamins and diet leads to a dramatic reduction in thrombotic events, even though patients...

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Bibliographische Detailangaben
Hauptverfasser: Gupta, Sapna, Kühnisch, Jirko, Mustafa, Aladdin, Lhotak, Sarka, Schlachterman, Alexander, Slifker, Michael J., Klein-Szanto, Andres, High, Katherine A., Austin, Richard C., Kruger, Warren D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Federation of American Societies for Experimental Biology 2009
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653989/
https://ncbi.nlm.nih.gov/pubmed/18987302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-120584
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