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Base Modification Strategies to Modulate Immune Stimulation by an siRNA
Immune stimulation triggered by siRNAs is one of the major challenges in the development of safe RNAi-based therapeutics. Within an immunostimulatory siRNA sequence, this hurdle is commonly addressed by using ribose modifications (e.g. 2′-OMe or 2′-F) which results in decreased cytokine production....
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| Publicado en: | Chembiochem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4337945/ https://ncbi.nlm.nih.gov/pubmed/25487859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402551 |
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