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Base Modification Strategies to Modulate Immune Stimulation by an siRNA
Immune stimulation triggered by siRNAs is one of the major challenges in the development of safe RNAi-based therapeutics. Within an immunostimulatory siRNA sequence, this hurdle is commonly addressed by using ribose modifications (e.g. 2′-OMe or 2′-F) which results in decreased cytokine production....
Enregistré dans:
| Publié dans: | Chembiochem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4337945/ https://ncbi.nlm.nih.gov/pubmed/25487859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402551 |
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