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Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation()

The development of receptor tyrosine-kinase inhibitors (TKIs) was a major step forward in cancer treatment. However, the therapy with TKIs is limited by strong side effects and drug resistance. The aim of this study was the design of novel epidermal growth factor receptor (EGFR) inhibitors that are...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Karnthaler-Benbakka, Claudia, Groza, Diana, Kryeziu, Kushtrim, Pichler, Verena, Roller, Alexander, Berger, Walter, Heffeter, Petra, Kowol, Christian R.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336855/
https://ncbi.nlm.nih.gov/pubmed/25079700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201403936
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