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Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation()
The development of receptor tyrosine-kinase inhibitors (TKIs) was a major step forward in cancer treatment. However, the therapy with TKIs is limited by strong side effects and drug resistance. The aim of this study was the design of novel epidermal growth factor receptor (EGFR) inhibitors that are...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4336855/ https://ncbi.nlm.nih.gov/pubmed/25079700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201403936 |
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