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Subinhibitory Concentrations of LFF571 Reduce Toxin Production by Clostridium difficile

LFF571 is a novel semisynthetic thiopeptide antibacterial that is undergoing investigation for safety and efficacy in patients with moderate Clostridium difficile infections. LFF571 inhibits bacterial protein synthesis by interacting with elongation factor Tu (EF-Tu) and interrupting complex formati...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Sachdeva, Meena, Leeds, Jennifer A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335859/
https://ncbi.nlm.nih.gov/pubmed/25512411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04436-14
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