A rare human syndrome provides genetic evidence that WNT signaling is required for reprogramming of fibroblasts to induced pluripotent stem cells

WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency. Fibroblasts from individuals with Focal Dermal Hypoplasia (FDH), a rare genetic syndrome caused by mutat...

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Foilsithe in:Cell Rep
Main Authors: Ross, Jason, Busch, Julia, Mintz, Ellen, Ng, Damian, Stanley, Alexandra, Brafman, David, Sutton, V. Reid, Van den Veyver, Ignatia, Willert, Karl
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335800/
https://ncbi.nlm.nih.gov/pubmed/25464842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.049
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