A rare human syndrome provides genetic evidence that WNT signaling is required for reprogramming of fibroblasts to induced pluripotent stem cells

WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency. Fibroblasts from individuals with Focal Dermal Hypoplasia (FDH), a rare genetic syndrome caused by mutat...

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Publicado en:Cell Rep
Main Authors: Ross, Jason, Busch, Julia, Mintz, Ellen, Ng, Damian, Stanley, Alexandra, Brafman, David, Sutton, V. Reid, Van den Veyver, Ignatia, Willert, Karl
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335800/
https://ncbi.nlm.nih.gov/pubmed/25464842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.049
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