A rare human syndrome provides genetic evidence that WNT signaling is required for reprogramming of fibroblasts to induced pluripotent stem cells

WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency. Fibroblasts from individuals with Focal Dermal Hypoplasia (FDH), a rare genetic syndrome caused by mutat...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Ross, Jason, Busch, Julia, Mintz, Ellen, Ng, Damian, Stanley, Alexandra, Brafman, David, Sutton, V. Reid, Van den Veyver, Ignatia, Willert, Karl
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335800/
https://ncbi.nlm.nih.gov/pubmed/25464842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.049
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