Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability

GLP and G9a are major H3K9 dimethylases and are essential for mouse early embryonic development. GLP and G9a both harbor ankyrin repeat domains that are capable of binding H3K9 methylation. However, the functional significance of their recognition of H3K9 methylation is unknown. Here, we report that...

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Vydáno v:Genes Dev
Hlavní autoři: Liu, Nan, Zhang, Zhuqiang, Wu, Hui, Jiang, Yonghua, Meng, Lingjun, Xiong, Jun, Zhao, Zuodong, Zhou, Xiaohua, Li, Jia, Li, Hong, Zheng, Yong, Chen, She, Cai, Tao, Gao, Shaorong, Zhu, Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335294/
https://ncbi.nlm.nih.gov/pubmed/25637356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.254425.114
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