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G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription
Methylation of DNA and lysine 9 of histone H3 (H3K9) are well-conserved epigenetic marks for transcriptional silencing. Although H3K9 methylation directs DNA methylation in filamentous fungi and plants, this pathway has not been corroborated in mammals. G9a and GLP/Eu-HMTase1 are two-related mammali...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2572175/ https://ncbi.nlm.nih.gov/pubmed/18818694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.192 |
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