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G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

Methylation of DNA and lysine 9 of histone H3 (H3K9) are well-conserved epigenetic marks for transcriptional silencing. Although H3K9 methylation directs DNA methylation in filamentous fungi and plants, this pathway has not been corroborated in mammals. G9a and GLP/Eu-HMTase1 are two-related mammali...

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Bibliographic Details
Main Authors: Tachibana, Makoto, Matsumura, Yasuko, Fukuda, Mikiko, Kimura, Hiroshi, Shinkai, Yoichi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572175/
https://ncbi.nlm.nih.gov/pubmed/18818694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.192
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