Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability

GLP and G9a are major H3K9 dimethylases and are essential for mouse early embryonic development. GLP and G9a both harbor ankyrin repeat domains that are capable of binding H3K9 methylation. However, the functional significance of their recognition of H3K9 methylation is unknown. Here, we report that...

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Liu, Nan, Zhang, Zhuqiang, Wu, Hui, Jiang, Yonghua, Meng, Lingjun, Xiong, Jun, Zhao, Zuodong, Zhou, Xiaohua, Li, Jia, Li, Hong, Zheng, Yong, Chen, She, Cai, Tao, Gao, Shaorong, Zhu, Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335294/
https://ncbi.nlm.nih.gov/pubmed/25637356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.254425.114
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