Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals

In mammals it is unclear if UHRF1-mediated DNA maintenance methylation by DNMT1 is strictly dependent on histone H3K9 methylation. Here we have generated an Uhrf1 knockin (KI) mouse model that specifically abolishes the H3K9me2/3-binding activity of Uhrf1. The homozygous Uhrf1 KI mice are viable and...

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Udgivet i:Nat Commun
Main Authors: Zhao, Qian, Zhang, Jiqin, Chen, Ruoyu, Wang, Lina, Li, Bo, Cheng, Hao, Duan, Xiaoya, Zhu, Haijun, Wei, Wei, Li, Jiwen, Wu, Qihan, Han, Jing-Dong J., Yu, Wenqiang, Gao, Shaorong, Li, Guohong, Wong, Jiemin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426519/
https://ncbi.nlm.nih.gov/pubmed/27554592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12464
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