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Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals
In mammals it is unclear if UHRF1-mediated DNA maintenance methylation by DNMT1 is strictly dependent on histone H3K9 methylation. Here we have generated an Uhrf1 knockin (KI) mouse model that specifically abolishes the H3K9me2/3-binding activity of Uhrf1. The homozygous Uhrf1 KI mice are viable and...
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| Izdano u: | Nat Commun |
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| Glavni autori: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5426519/ https://ncbi.nlm.nih.gov/pubmed/27554592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12464 |
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