Germ Line Variants of Human N-Methylpurine DNA Glycosylase Show Impaired DNA Repair Activity and Facilitate 1,N(6)-Ethenoadenine-induced Mutations

Human N-methylpurine DNA glycosylase (hMPG) initiates base excision repair of a number of structurally diverse purine bases including 1,N(6)-ethenoadenine, hypoxanthine, and alkylation adducts in DNA. Genetic studies discovered at least eight validated non-synonymous single nucleotide polymorphisms...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Adhikari, Sanjay, Chetram, Mahandranauth A., Woodrick, Jordan, Mitra, Partha S., Manthena, Praveen V., Khatkar, Pooja, Dakshanamurthy, Sivanesan, Dixon, Monica, Karmahapatra, Soumendra K., Nuthalapati, Nikhil K., Gupta, Suhani, Narasimhan, Ganga, Mazumder, Raja, Loffredo, Christopher A., Üren, Aykut, Roy, Rabindra
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
DNA and Chromosomes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335234/
https://ncbi.nlm.nih.gov/pubmed/25538240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627000
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