Germ Line Variants of Human N-Methylpurine DNA Glycosylase Show Impaired DNA Repair Activity and Facilitate 1,N(6)-Ethenoadenine-induced Mutations

Human N-methylpurine DNA glycosylase (hMPG) initiates base excision repair of a number of structurally diverse purine bases including 1,N(6)-ethenoadenine, hypoxanthine, and alkylation adducts in DNA. Genetic studies discovered at least eight validated non-synonymous single nucleotide polymorphisms...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Adhikari, Sanjay, Chetram, Mahandranauth A., Woodrick, Jordan, Mitra, Partha S., Manthena, Praveen V., Khatkar, Pooja, Dakshanamurthy, Sivanesan, Dixon, Monica, Karmahapatra, Soumendra K., Nuthalapati, Nikhil K., Gupta, Suhani, Narasimhan, Ganga, Mazumder, Raja, Loffredo, Christopher A., Üren, Aykut, Roy, Rabindra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335234/
https://ncbi.nlm.nih.gov/pubmed/25538240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627000
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