Germ Line Variants of Human N-Methylpurine DNA Glycosylase Show Impaired DNA Repair Activity and Facilitate 1,N(6)-Ethenoadenine-induced Mutations

Human N-methylpurine DNA glycosylase (hMPG) initiates base excision repair of a number of structurally diverse purine bases including 1,N(6)-ethenoadenine, hypoxanthine, and alkylation adducts in DNA. Genetic studies discovered at least eight validated non-synonymous single nucleotide polymorphisms...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Adhikari, Sanjay, Chetram, Mahandranauth A., Woodrick, Jordan, Mitra, Partha S., Manthena, Praveen V., Khatkar, Pooja, Dakshanamurthy, Sivanesan, Dixon, Monica, Karmahapatra, Soumendra K., Nuthalapati, Nikhil K., Gupta, Suhani, Narasimhan, Ganga, Mazumder, Raja, Loffredo, Christopher A., Üren, Aykut, Roy, Rabindra
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2015
主題:
DNA and Chromosomes
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335234/
https://ncbi.nlm.nih.gov/pubmed/25538240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627000
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