Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction

BACKGROUND: Topo-poisons can produce an enzyme-DNA complex linked by a 3'- or 5'-phosphotyrosyl covalent bond. 3'-phosphotyrosyl bonds can be repaired by tyrosyl DNA phosphodiesterase-1 (TDP1), an enzyme known for years, but a complementary human enzyme 5'-tyrosyl DNA phosphodies...

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Detalhes bibliográficos
Main Authors: Adhikari, Sanjay, Karmahapatra, Soumendra K, Karve, Tejaswita M, Bandyopadhyay, Sanjona, Woodrick, Jordan, Manthena, Praveen V, Glasgow, Eric, Byers, Stephen, Saha, Tapas, Uren, Aykut
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315744/
https://ncbi.nlm.nih.gov/pubmed/22405347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-5-134
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