Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

Inheritance of the ε4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor associated with the sporadic form of Alzheimer's disease (AD), whereas the rare APOE ε2 allele has the opposite effect. However, the mechanisms whereby APOE confers risk and protection remain uncertain....

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Pubblicato in:Sci Transl Med
Autori principali: Hudry, Eloise, Dashkoff, Jonathan, Roe, Alysson D., Takeda, Shuko, Koffie, Robert M., Hashimoto, Tadafumi, Scheel, Maria, Spires-Jones, Tara, Arbel-Ornath, Michal, Betensky, Rebecca, Davidson, Beverly L., Hyman, Bradley T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334150/
https://ncbi.nlm.nih.gov/pubmed/24259049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007000
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