Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

Inheritance of the ε4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor associated with the sporadic form of Alzheimer's disease (AD), whereas the rare APOE ε2 allele has the opposite effect. However, the mechanisms whereby APOE confers risk and protection remain uncertain....

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sci Transl Med
Asıl Yazarlar: Hudry, Eloise, Dashkoff, Jonathan, Roe, Alysson D., Takeda, Shuko, Koffie, Robert M., Hashimoto, Tadafumi, Scheel, Maria, Spires-Jones, Tara, Arbel-Ornath, Michal, Betensky, Rebecca, Davidson, Beverly L., Hyman, Bradley T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334150/
https://ncbi.nlm.nih.gov/pubmed/24259049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007000
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller