REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ

DNA polymerase zeta (pol ζ) is exceptionally important for controlling mutagenesis and genetic instability. REV3L comprises the catalytic subunit, while REV7 (MAD2L2) is considered an accessory subunit. However, it has not been established that the role of REV7 in DNA damage tolerance is necessarily...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Tomida, Junya, Takata, Kei-ichi, Lange, Sabine S., Schibler, Andria C., Yousefzadeh, Matthew J., Bhetawal, Sarita, Dent, Sharon Y.R., Wood, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333420/
https://ncbi.nlm.nih.gov/pubmed/25567983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1385
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