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The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability

DNA polymerase ζ (pol ζ) is exceptionally important for maintaining genome stability. Inactivation of the Rev3l gene encoding the polymerase catalytic subunit causes a high frequency of chromosomal breaks, followed by lethality in mouse embryos and in primary cells. Yet it is not known whether the D...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Lange, Sabine S., Tomida, Junya, Boulware, Karen S., Bhetawal, Sarita, Wood, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699697/
https://ncbi.nlm.nih.gov/pubmed/26727495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005759
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