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Disruption of DNA polymerase ζ engages an innate immune response
In mammalian cells, specialized DNA polymerase ζ (pol ζ) contributes to genomic stability during normal DNA replication. Disruption of the catalytic subunit Rev3l is toxic and results in constitutive chromosome damage· including micronuclei. As manifestations of this genomic stress are unknown· we e...
Gorde:
| Argitaratua izan da: | Cell Rep |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2021
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7990024/ https://ncbi.nlm.nih.gov/pubmed/33626348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108775 |
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