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Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses
DNA polymerase ζ (polζ) is critical for bypass of DNA damage and the associated mutagenesis, but also has unique functions in mammals. It is required for embryonic development and for viability of hematopoietic cells, but, paradoxically, skin epithelia appear to survive polζ deletion. We wished to d...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581960/ https://ncbi.nlm.nih.gov/pubmed/23386725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217425110 |
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