Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses

DNA polymerase ζ (polζ) is critical for bypass of DNA damage and the associated mutagenesis, but also has unique functions in mammals. It is required for embryonic development and for viability of hematopoietic cells, but, paradoxically, skin epithelia appear to survive polζ deletion. We wished to d...

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Detalhes bibliográficos
Main Authors: Lange, Sabine S., Bedford, Ella, Reh, Shelley, Wittschieben, John P., Carbajal, Steve, Kusewitt, Donna F., DiGiovanni, John, Wood, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581960/
https://ncbi.nlm.nih.gov/pubmed/23386725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217425110
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