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DNA polymerase zeta is required for proliferation of normal mammalian cells

Unique among translesion synthesis (TLS) DNA polymerases, pol ζ is essential during embryogenesis. To determine whether pol ζ is necessary for proliferation of normal cells, primary mouse fibroblasts were established in which Rev3L could be conditionally inactivated by Cre recombinase. Cells were gr...

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書目詳細資料
Main Authors: Lange, Sabine S., Wittschieben, John P., Wood, Richard D.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378892/
https://ncbi.nlm.nih.gov/pubmed/22319213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks054
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