DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure

Routine dietary consumption of foods that contain aflatoxins is the second leading cause of environmental carcinogenesis worldwide. Aflatoxin-driven mutagenesis is initiated through metabolic activation of aflatoxin B(1) (AFB(1)) to its epoxide form that reacts with N7 guanine in DNA. The resulting...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lin, Ying-Chih, Owen, Nichole, Minko, Irina G., Lange, Sabine S., Tomida, Junya, Li, Liang, Stone, Michael P., Wood, Richard D., McCullough, Amanda K., Lloyd, R. Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137696/
https://ncbi.nlm.nih.gov/pubmed/27849610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609024113
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