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High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5
RIG-I and MDA5 are the major intracellular immune receptors that recognize viral RNA species and undergo a series of conformational transitions leading to the activation of the interferon-mediated antiviral response. However, to date, full-length RLRs have resisted crystallographic efforts and a mol...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4333383/ https://ncbi.nlm.nih.gov/pubmed/25539915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1329 |
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