High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5

RIG-I and MDA5 are the major intracellular immune receptors that recognize viral RNA species and undergo a series of conformational transitions leading to the activation of the interferon-mediated antiviral response. However, to date, full-length RLRs have resisted crystallographic efforts and a mol...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Zheng, Jie, Yong, Hui Yee, Panutdaporn, Nantika, Liu, Chuanfa, Tang, Kai, Luo, Dahai
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333383/
https://ncbi.nlm.nih.gov/pubmed/25539915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1329
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