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DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
In the current model of DNA SSBR, PARP1 is regarded as the sensor of single-strand breaks (SSBs). However, biochemical studies have implicated LIG3 as another possible SSB sensor. Using a laser micro-irradiation protocol that predominantly generates SSBs, we were able to demonstrate that PARP1 is di...
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| Опубликовано в: : | Nucleic Acids Res |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4333375/ https://ncbi.nlm.nih.gov/pubmed/25539916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1307 |
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