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Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF
The repair of DNA double-strand breaks by nonhomologous end-joining (NHEJ) is essential for maintenance of genomic integrity and cell viability. Central to the molecular mechanism of NHEJ is DNA ligase IV/XRCC4/XLF complex, which rejoins the DNA. During adenovirus (Ad5) infection, ligase IV is targe...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2566893/ https://ncbi.nlm.nih.gov/pubmed/18782835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn552 |
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