Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors

DNA double-strand breaks (DSBs) are fatal DNA lesions and activate a rapid DNA damage response. However, the earliest stage of DSB sensing remains elusive. Here, we report that PARP1 and the Ku70/80 complex localize to DNA lesions considerably earlier than other DSB sensors. Using super-resolved flu...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Yang, Guang, Liu, Chao, Chen, Shih-Hsun, Kassab, Muzaffer A, Hoff, J Damon, Walter, Nils G, Yu, Xiaochun
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909444/
https://ncbi.nlm.nih.gov/pubmed/29447383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky088
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