Dynamic Switching of Active Promoter and Enhancer Domains Regulates Tet1 and Tet2 Expression during Cell State Transitions between Pluripotency and Differentiation

The Tet 5-methylcytosine dioxygenases catalyze DNA demethylation by producing 5-hydroxymethylcytosine and further oxidized products. Tet1 and Tet2 are highly expressed in mouse pluripotent cells and downregulated to different extents in somatic cells, but the transcriptional mechanisms are unclear....

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Vydáno v:Mol Cell Biol
Hlavní autoři: Sohni, Abhishek, Bartoccetti, Michela, Khoueiry, Rita, Spans, Lien, Vande Velde, Joris, De Troyer, Linde, Pulakanti, Kirthi, Claessens, Frank, Rao, Sridhar, Koh, Kian Peng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333094/
https://ncbi.nlm.nih.gov/pubmed/25582196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01172-14
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