Dynamic Switching of Active Promoter and Enhancer Domains Regulates Tet1 and Tet2 Expression during Cell State Transitions between Pluripotency and Differentiation

The Tet 5-methylcytosine dioxygenases catalyze DNA demethylation by producing 5-hydroxymethylcytosine and further oxidized products. Tet1 and Tet2 are highly expressed in mouse pluripotent cells and downregulated to different extents in somatic cells, but the transcriptional mechanisms are unclear....

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Publicado no:Mol Cell Biol
Main Authors: Sohni, Abhishek, Bartoccetti, Michela, Khoueiry, Rita, Spans, Lien, Vande Velde, Joris, De Troyer, Linde, Pulakanti, Kirthi, Claessens, Frank, Rao, Sridhar, Koh, Kian Peng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333094/
https://ncbi.nlm.nih.gov/pubmed/25582196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01172-14
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