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Glycosylated Neurotensin Analogs Exhibit the Subpicomolar Anticonvulsant Potency in the Pharmacoresistant Model of Epilepsy
Neurotensin (NT) is an endogenous neuropeptide involved in a variety of central and peripheral neuromodulatory effects. Here we show effects of site-specific glycosylation on the in vitro and in vivo pharmacological properties of this neuropeptide. NT analogs containing O-linked disaccharides (β-mel...
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| Pubblicato in: | ChemMedChem |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4332545/ https://ncbi.nlm.nih.gov/pubmed/19173215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200800421 |
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