A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties

Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence similarity at the C-terminus, which is critical for a...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Lee, Hee-Kyoung, Zhang, Liuyin, Smith, Misty D., Walewska, Aleksandra, Vellore, Nadeem A., Baron, Riccardo, McIntosh, J. Michael, White, H. Steve, Olivera, Baldomero M., Bulaj, Grzegorz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322620/
https://ncbi.nlm.nih.gov/pubmed/25713532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00011
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