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Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress
Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms. The precise mechanism underlying the effects of the IIS on lifespan and health is currently unclear, although cellular stress resistance may be...
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| Publicado no: | Aging Cell |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331740/ https://ncbi.nlm.nih.gov/pubmed/25059507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12255 |
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