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Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage

Insulin receptor substrate-1 null (Irs1(−/−)) mice are long lived and importantly they also demonstrate increased resistance to several age-related pathologies compared to wild type (WT) controls. Currently, the molecular mechanisms that underlie lifespan extension in long-lived mice are unclear alt...

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Autors principals: Page, Melissa M., Withers, Dominic J., Selman, Colin
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636410/
https://ncbi.nlm.nih.gov/pubmed/22371226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-012-9395-9
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