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Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage
Insulin receptor substrate-1 null (Irs1(−/−)) mice are long lived and importantly they also demonstrate increased resistance to several age-related pathologies compared to wild type (WT) controls. Currently, the molecular mechanisms that underlie lifespan extension in long-lived mice are unclear alt...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3636410/ https://ncbi.nlm.nih.gov/pubmed/22371226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-012-9395-9 |
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